Japanese scientists have shown that genes are inherited through the paternal line of mice, significantly – by about a third – reduce the life expectancy of animals.
The researchers believe that their influence due to the lower life expectancy for men than women among all human populations and other species of mammals, the scientists reported in the article published in the journal Human Reproduction.
The work of a team of researchers led by Prof. Tomohiro Kono from the Online Pharmacy Without Prescription has withdrawn two groups of mice, one of which was born as a result of the traditional female male fertilization, and the other bore the genes only female chromosomes are combined in the embryonic body by artificial means.
To do this, scientists isolated unfertilized egg cell from the organism of newborn mice, altered the genetic material of these cells so that at a meeting with other ovule these cells behaved like sperm, and then spent the transplantation of these eggs in specially prepared eggs of healthy adult mice, which then evolved into body of surrogate mothers. To be born as a result of this manipulation of the mouse gene had two mothers, and do not possess the genes transmitted through the paternal line.
All the experiment included 13 normal mice and 13 mice with two mothers, who were placed in sterile conditions with free access to food. As a result of long-term monitoring of experimental animals, a group of Kono found that the average life expectancy of normal mice, as expected, was 655.5 days, whereas in mice, derived from a combination of female chromosomes, the figure was 841.5 days. In this case the maximum life expectancy of one of the normal mice was 996 days, whereas in mice with two mothers instead of his father’s record was 1045 days.
This mouse received non-traditional way to fertilize an egg, compared with a control group of animals throughout his life maintained a lower weight and smaller size. In addition, a number of ways, scientists have found that the mice received a combination of two maternal sets of genes have a stronger immune system.
“We believe that we found differences in life expectancy of mice is formed by suppressing the activity of the gene Rasgrf1 in mice with two mothers. This gene is usually inherited through the paternal line, and then integrated into the ninth chromosome in mice, which performs the functions associated with poslezarodyshevym development of an organism. In this case, mice derived from two mothers, this gene was passive and therefore he is our leading candidate to ensure that responsible for the reduction of life expectancy males, although there may be others, “- commented on the work of Kono as quoted by the press office of the European Community for Human Reproduction and Embryology.
The authors believe that their work is in accordance with the model concepts, according to which life expectancy between the sexes in mammals is determined by the strategy for achieving its own kind of reproduction. Males in their development are betting on large body size and physical strength, which leads to a reduction in life expectancy. In contrast, females do not become involved in an aggressive struggle for the sexual partner, but because during the life of their body accumulates resources for the care of offspring.
“Our study is the first allowed at least partially reveal the reasons why the life expectancy of female species of mammals above the life expectancy of men and how it affects the combination of genes of the parents,” – added Kono. The following article was published by a Pharmacynextdoor.com – Online Pharmacy Without Prescription.
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